Simvastatin Side Effects & History of Statins
Simvastatin, like almost any
other beneficial medicine, may cause side effects for some patients. Before we
go into simvastatin side effects, let’s bring in a little history about
statins.
When statins first came on the market, manufacturers included a notice about muscle cramps, aches, pain, and weakness. In the late 1980s, it was clear that statins may trigger rhabdontyolysis, an excessive breakdown of muscle tissue creating a flood of waste cells that tumble through the bloodstream and into the kidneys where they may clog small passages and — theoretically — cause kidney failure.
When statins first came on the market, manufacturers included a notice about muscle cramps, aches, pain, and weakness. In the late 1980s, it was clear that statins may trigger rhabdontyolysis, an excessive breakdown of muscle tissue creating a flood of waste cells that tumble through the bloodstream and into the kidneys where they may clog small passages and — theoretically — cause kidney failure.
Today, the package inserts for all statin drugs
include a warning about muscle pain & other possible side effects, which
commonly include at least temporarily abnormal results on tests for liver
enzymes, allergic rash, fatigue, headache and dizziness, low blood pressure,
upset stomach (nausea, gas, diarrhea, or constipation).
The following list details the currently
recognized simvastatin side effects:
Contact your doctor
if you experience
- severe constipation
- stomach pain
- headache
- nausea
or if you are experiencing any of these symptoms
& they won’t go away.
Some side effects may be serious.
Call your doctor immediately if you experience:
- muscle pain, tenderness, weakness
- dark red urine
- fever or chills
- difficulty breathing or swallowing
- swelling of the face, lips, tongue, throat, eyes, feet, hands, lower legs or ankles
- tiredness, lack of energy or weakness
- itching
- joint pain
- rash
- flushing
- hoarseness
- blisters
- sensitivity to light
- hives
If you experience muscle pain, tenderness,
weakness, dark red urine, lack of energy, tiredness, or weakness don’t
take more simvastatin without consulting with your doctor:
Simvastatin can cause other not mentioned side
effects. Contact your doctor if you encounter any uncommon or strange problems
while you’re taking it.
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